SML1795
Tenofovir
≥98% (HPLC), DNA chain terminator, powder
Synonym(s):
(R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
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About This Item
Empirical Formula (Hill Notation):
C9H14N5O4P
CAS Number:
Molecular Weight:
287.21
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Product Name
Tenofovir, ≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -20 to -26°, c = 0.5 in 1 M HCl
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
InChI
1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChI key
SGOIRFVFHAKUTI-ZCFIWIBFSA-N
Related Categories
Biochem/physiol Actions
Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.
Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription.
Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Courtney Sakolish et al.
Drug metabolism and disposition: the biological fate of chemicals (2024-04-17)
In vitro models that can faithfully replicate critical aspects of kidney tubule function such as directional drug transport are in high demand in pharmacology and toxicology. Accordingly, development and validation of new models is underway. The objective of this study
Tracy P Trang et al.
Expert opinion on drug safety, 15(9), 1287-1294 (2016-07-09)
Tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) are nucleoside reverse transcriptase inhibitors approved as pre-exposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). Prophylactic TDF-based regimens have been shown to reduce the risk of HIV infection by 74 to 92% among
Kevin R Robertson et al.
AIDS (London, England), 30(15), 2315-2321 (2016-06-23)
The objective was to determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART). Randomized, double-blind, placebo-controlled, 48-week trial. Participants were enrolled in US AIDS Clinical Trials Group clinical trial sites. Total 262 ART-naive
Setjie W Maepa et al.
Bio-protocol, 14(15), e5042-e5042 (2024-08-12)
The liver is an essential organ that is involved in the metabolism, synthesis, and secretion of serum proteins and detoxification of xenobiotic compounds and alcohol. Studies on liver diseases have largely relied on cancer-derived cell lines that have proven to
B L Robbins et al.
Antimicrobial agents and chemotherapy, 42(3), 612-617 (1998-03-28)
Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA] has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood lymphocytes. This improved efficacy
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