SML1795
Tenofovir
≥98% (HPLC), DNA chain terminator, powder
Synonym(s):
(R)-9-(2-Phosphonomethoxypropyl)adenine, (R)-PMPA
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About This Item
Empirical Formula (Hill Notation):
C9H14N5O4P
CAS Number:
Molecular Weight:
287.21
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Tenofovir, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -20 to -26°, c = 0.5 in 1 M HCl
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
OP(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)(O)=O
InChI
1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChI key
SGOIRFVFHAKUTI-ZCFIWIBFSA-N
Biochem/physiol Actions
Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus.
Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription.
Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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