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Merck
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SML1846

Sigma-Aldrich

Ochratoxin A Ready Made Solution

1 mg/mL in DMSO, from Petromyces albertensis

Synonym(s):

N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine, OTA

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About This Item

Empirical Formula (Hill Notation):
C20H18ClNO6
CAS Number:
303-47-9
Molecular Weight:
403.81
UNSPSC Code:
12352200

Key Documents

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biological source

Petromyces albertensis

Quality Level

200

Assay

≥98%

form

DMSO solution

concentration

1 mg/mL in DMSO

storage temp.

2-8°C

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1

InChI key

RWQKHEORZBHNRI-BMIGLBTASA-N

Application

For ELISA assay, dilute the provided 1 mg/ml solution to 0.4, 1.0, 2.0, 4.0, and 8.0ng/ml in organic solvent.

Biochem/physiol Actions

Ochratoxin A (OTA) is a mycotoxin derived from Aspergillus ochraceus, Petromyces albertensis, Penicillium verrucosum, and others. Ochratoxin A was found in numerous food sources including cereals, dog food, beer and wine. Several studies suggest that Ochratoxin A toxicity may result in nephropathies, carcinogenicity, and teratogenicity.
Ochratoxin A (OTA) is a mycotoxin.
Ochratoxin A (OTA) is nephrotoxic, and can stimulate cytoprotective autophagy by inhibiting AKT/mammalian target of rapamycin (mTOR) signaling pathway in PK-15 cells. It is expected to be an etiological agent accountable for human Balkan endemic nephropathy (BEN). OTA is linked with urinary tract tumors.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000080661
017M4033V
11170101

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E Razzazi et al.
Journal of animal physiology and animal nutrition, 85(7-8), 212-216 (2001-11-01)
The occurrence of ochratoxin A (OTA) in canned (26 samples) as well as dry pet foods (17 samples) for cats and dogs was investigated. In addition, 26 feline kidney samples with or without kidney alterations were surveyed for OTA-residues. The
S C Duarte et al.
Food microbiology, 27(2), 187-198 (2010-02-10)
Ochratoxin A (OTA) continues to grab global attention and concern for the hazard and impact that embody for both human and animals, based on its toxicity and occurrence. Despite OTA has been described in a myriad of foodstuffs, cereal and
Francisco Javier Cabañes et al.
Toxins, 2(5), 1111-1120 (2010-05-01)
Ochratoxin A (OTA) producing fungi are members of the genera Aspergillus and Penicillium. Nowadays, there are about 20 species accepted as OTA producers, which are distributed in three phylogenetically related but distinct groups of aspergilli of the subgenus Circumdati and
M Peraica et al.
Bulletin of the World Health Organization, 77(9), 754-766 (1999-10-27)
Mycotoxicoses are diseases caused by mycotoxins, i.e. secondary metabolites of moulds. Although they occur more frequently in areas with a hot and humid climate, favourable for the growth of moulds, they can also be found in temperate zones. Exposure to
Rufino Mateo et al.
International journal of food microbiology, 119(1-2), 79-83 (2007-08-25)
Ochratoxin A (OTA) is a mycotoxin produced mainly by several fungal species of the genera Aspergillus and Penicillium. This mycotoxin has been shown to be nephrotoxic, hepatotoxic, teratogenic and carcinogenic to animals and has been classified as a possible carcinogen
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