SML1846
Ochratoxin A Ready Made Solution
1 mg/mL in DMSO, from Petromyces albertensis
Synonym(s):
N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine, OTA
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About This Item
Empirical Formula (Hill Notation):
C20H18ClNO6
CAS Number:
Molecular Weight:
403.81
UNSPSC Code:
12352200
InChI key
RWQKHEORZBHNRI-BMIGLBTASA-N
InChI
1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
biological source
Petromyces albertensis
assay
≥98%
form
DMSO solution
concentration
1 mg/mL in DMSO
storage temp.
2-8°C
Quality Level
Application
For ELISA assay, dilute the provided 1 mg/ml solution to 0.4, 1.0, 2.0, 4.0, and 8.0ng/ml in organic solvent.
Biochem/physiol Actions
Ochratoxin A (OTA) is a mycotoxin derived from Aspergillus ochraceus, Petromyces albertensis, Penicillium verrucosum, and others. Ochratoxin A was found in numerous food sources including cereals, dog food, beer and wine. Several studies suggest that Ochratoxin A toxicity may result in nephropathies, carcinogenicity, and teratogenicity.
Ochratoxin A (OTA) is a mycotoxin.
Ochratoxin A (OTA) is nephrotoxic, and can stimulate cytoprotective autophagy by inhibiting AKT/mammalian target of rapamycin (mTOR) signaling pathway in PK-15 cells. It is expected to be an etiological agent accountable for human Balkan endemic nephropathy (BEN). OTA is linked with urinary tract tumors.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F
flash_point_c
87 °C
Regulatory Information
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S C Duarte et al.
Food microbiology, 27(2), 187-198 (2010-02-10)
Ochratoxin A (OTA) continues to grab global attention and concern for the hazard and impact that embody for both human and animals, based on its toxicity and occurrence. Despite OTA has been described in a myriad of foodstuffs, cereal and
E Razzazi et al.
Journal of animal physiology and animal nutrition, 85(7-8), 212-216 (2001-11-01)
The occurrence of ochratoxin A (OTA) in canned (26 samples) as well as dry pet foods (17 samples) for cats and dogs was investigated. In addition, 26 feline kidney samples with or without kidney alterations were surveyed for OTA-residues. The
Francisco Javier Cabañes et al.
Toxins, 2(5), 1111-1120 (2010-05-01)
Ochratoxin A (OTA) producing fungi are members of the genera Aspergillus and Penicillium. Nowadays, there are about 20 species accepted as OTA producers, which are distributed in three phylogenetically related but distinct groups of aspergilli of the subgenus Circumdati and
M Peraica et al.
Bulletin of the World Health Organization, 77(9), 754-766 (1999-10-27)
Mycotoxicoses are diseases caused by mycotoxins, i.e. secondary metabolites of moulds. Although they occur more frequently in areas with a hot and humid climate, favourable for the growth of moulds, they can also be found in temperate zones. Exposure to
Rufino Mateo et al.
International journal of food microbiology, 119(1-2), 79-83 (2007-08-25)
Ochratoxin A (OTA) is a mycotoxin produced mainly by several fungal species of the genera Aspergillus and Penicillium. This mycotoxin has been shown to be nephrotoxic, hepatotoxic, teratogenic and carcinogenic to animals and has been classified as a possible carcinogen
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