SML1849
TP-064 TFA salt
≥98% (HPLC)
Synonym(s):
N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C28H34N4O2 · CF3CO2H
Molecular Weight:
572.62
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to brown
solubility
DMSO: 10 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C(N(CC1=CC(C2CCN(CCNC)CC2)=NC=C1)C)C3=CC=CC(OC4=CC=CC=C4)=C3.FC(F)(C(O)=O)F
Biochem/physiol Actions
TP-064 is a selective chemical probe for protein arginine methyltransferase 4 (PRMT4) developed out of a collaborative effort by Takeda and the SGC. TP-064 inhibited PRMT4 with an IC50 value < 10 nM for methylation of H3 (1-25). It showed greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cellular assays, TP-064 inhibited the methylation of MED12 with an IC50 value of 43 nM. For full characterization details, please visit the TP-064 probe summary on the Structural Genomics Consortium (SGC) website.
TP-064N is the negative control for the active probe, TP-064. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
TP-064N is the negative control for the active probe, TP-064. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
TP-064 is a selective chemical probe for protein arginine methyltransferase 4 (PRMT4).
Features and Benefits
TP-064 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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