SML1934
DR4004 hydrochloride
≥98% (HPLC)
Synonym(s):
1-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-2a,3,4,5-tetrahydro-1H-benzo[cd]indol-2-one, 2a-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one, DR 4004
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About This Item
Empirical Formula (Hill Notation):
C26H30N2O · HCl
CAS Number:
Molecular Weight:
422.99
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
DR4004 is a potent and selective 5-HT7 serotonin receptor antagonist.
Potent and selective 5-HT7 serotonin receptor antagonist
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kotaro Takeda et al.
Neuroscience letters, 638, 69-75 (2016-12-13)
Fear conditioning is a valuable behavioral paradigm for studying the neural basis of emotional learning and memory. The present study examined the involvement of extracellular signal-regulated kinase 1/2 (ERK) signaling on the serotonin (5-HT)
Hiroshi Takeda et al.
European journal of pharmacology, 518(1), 30-39 (2005-07-09)
The present study examined whether serotonin (5-hydroxytryptamine; 5-HT)7 receptors play a role in the modulation of emotionality in mice using the selective 5-HT7 receptor antagonist 2a-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl)butyl]-2a,3,4,5-tetrahydrobenzo (c,d)indol-2-(1H)-one (DR4004). The emotionality of mice was evaluated in terms of exploratory activity in
Kazumasa Horikawa et al.
Journal of pharmacological sciences, 123(4), 402-406 (2013-12-03)
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The
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