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SML1946

AM-9074

≥98% (HPLC)

Synonym(s):

(R)-1-(4-((5-Methoxypyridin-3-yl)oxy)-5-(tetrahydro-2H-pyran-3-yl)pyridin-2-yl)-3-methylurea, Urea, N-[4-[(5-methoxy-3-pyridinyl)oxy]-5-[(3R)-tetrahydro-2H-pyran-3-yl]-2-pyridinyl]-N′-methyl-

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About This Item

Empirical Formula (Hill Notation):
C18H22N4O4
CAS Number:
1442677-92-0
Molecular Weight:
358.39
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNC(NC1=CC(OC2=CC(OC)=CN=C2)=C([C@H]3CCCOC3)C=N1)=O

InChI

1S/C18H22N4O4/c1-19-18(23)22-17-7-16(26-14-6-13(24-2)8-20-9-14)15(10-21-17)12-4-3-5-25-11-12/h6-10,12H,3-5,11H2,1-2H3,(H2,19,21,22,23)/t12-/m0/s1

InChI key

APSOPISMEDAYTH-LBPRGKRZSA-N

Biochem/physiol Actions

AM-9074 is a potent activator of glucokinase, which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-9074 had an EC50 value of 160 nM with good solubility, oral bioavailability and acceptable clearance in rodents, and was shown to lower plasma glucose levels.
Glucokinase activator

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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