SML1954
X-34
≥90% (HPLC), powder, amyloid-specific fluorescent dye
Synonym(s):
1,4-Bis(3-carboxy-4-hydroxyphenylethenyl)benzene
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About This Item
Empirical Formula (Hill Notation):
C24H18O6
CAS Number:
Molecular Weight:
402.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
Product Name
X-34, ≥90% (HPLC)
Quality Segment
assay
≥90% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2.0 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
InChI
1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
InChI key
MCBNOAYTZBUCSX-UHFFFAOYSA-N
Biochem/physiol Actions
X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer′s disease (AD).
Fluorescent, amyloid-specific dye
X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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