SML2000
3-BrOP
≥98% (GC)
Synonym(s):
3-BrPA propyl ester, 3-Bromo-2-oxopropionate-1-propyl ester, 3-Bromopyruvate propyl ester, Glycolycin, Propyl 3-bromo-2-oxopropanoate
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About This Item
Empirical Formula (Hill Notation):
C6H9BrO3
CAS Number:
Molecular Weight:
209.04
UNSPSC Code:
12352200
Assay:
≥98% (GC)
Form:
oil
assay
≥98% (GC)
form
oil
color
colorless to yellow
shipped in
ambient
storage temp.
2-8°C
Biochem/physiol Actions
3-BrOP is a cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) that is known to target hexokinase II (HK2) and GAPDH. Upon entering the cells, 3-BrOP is hydrolyzed by intracellular esterase to 3-BrPA. 3-BrOP is shown to synergize cancer cell killing with mTOR inhibitor rapamycin (apoptosis induction with/without 100 ng/mL rapamycin = 64%/36% of Raji human lymphoma cells by 40 μM 3-BrOP and 72%/45% of HL-60 leukemia cells by 20 μM 3-BrOP in 24 h) due to enhanced cellular ATP depletion and glucose uptake inhibition. When administered via tail vein injection, 3-BrOP significantly suppersses SK-N-SH xenograft-derived neuroblastoma tumor growth in mice in vivo (by 78% in 14 days; 20 mg/kg/day).
Cell-permeable ester of the the glycolysis inhibitor 3-bromopyruvate (3-BrPA) with in vitro and in vivo anti-cancer efficacy.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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