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Merck
CN

SML2114

ZD7155 hydrochloride

≥97% (HPLC)

Synonym(s):

5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, ZD 7155

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About This Item

Empirical Formula (Hill Notation):
C26H26N6O · HCl
CAS Number:
146709-78-6
Molecular Weight:
474.99
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00921888
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated

Key Documents

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InChI

1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H

SMILES string

CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl

InChI key

NAGGAAHTUXEGFG-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

Selective Angiotensin II AT1 antagonist
ZD7155 is a potent selective Angiotensin II AT1 antagonist. In one study ZD 7155 was found to be longer-acting and approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000038457
0000038456
0000032436

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I L Junggren et al.
The Journal of pharmacy and pharmacology, 48(8), 829-833 (1996-08-01)
Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study this novel substance was studied in normotensive and hypertensive rats. The relative potency and duration of the antihypertensive effects of ZD 7155
Signal Transduction and Targeted Therapy
Aung Than, Shaohai Xu, Ru Li, MelvinKhee-Shing Leow, Lei Sun and Peng Chen
Nature Chemical Biology, 2 (2017)
Haitao Zhang et al.
Nature, 544(7650), 327-332 (2017-04-06)
The angiotensin II receptors AT

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