SML2189
L-Moses
≥98% (HPLC)
Synonym(s):
(1S,2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenyl-1,2-propanediamine, L-45
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About This Item
Empirical Formula (Hill Notation):
C21H24N6
CAS Number:
Molecular Weight:
360.46
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC1=NN=C2N1N=C(N[C@@H](C)[C@@H](N(C)C)C3=CC=CC=C3)C4=CC=CC=C42
Biochem/physiol Actions
L-Moses is a cell penetrant, potent and selective PCAF bromodomain (Brd) inhibitor.
PCAF Bromodomain inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Andre Richters et al.
Current medicinal chemistry, 24(37), 4121-4150 (2017-02-28)
Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription factor activation. Histone deacetylases (HDACs) conduct the reverse
Moses Moustakim et al.
Angewandte Chemie (International ed. in English), 56(3), 827-831 (2016-12-15)
The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as