SML2189
L-Moses
≥98% (HPLC)
Synonym(s):
(1S,2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenyl-1,2-propanediamine, L-45
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C21H24N6
CAS Number:
Molecular Weight:
360.46
UNSPSC Code:
12352200
MDL number:
form
powder
SMILES string
CC1=NN=C2N1N=C(N[C@@H](C)[C@@H](N(C)C)C3=CC=CC=C3)C4=CC=CC=C42
assay
≥98% (HPLC)
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
L-Moses is a cell penetrant, potent and selective PCAF bromodomain (Brd) inhibitor.
PCAF Bromodomain inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Andre Richters et al.
Current medicinal chemistry, 24(37), 4121-4150 (2017-02-28)
Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription factor activation. Histone deacetylases (HDACs) conduct the reverse
Moses Moustakim et al.
Angewandte Chemie (International ed. in English), 56(3), 827-831 (2016-12-15)
The p300/CBP-associated factor (PCAF) and related GCN5 bromodomain-containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine-based L-45 (dubbed L-Moses) as
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service