SML2267
GeA-69
≥98% (HPLC)
Synonym(s):
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
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About This Item
Empirical Formula (Hill Notation):
C20H16N2O
CAS Number:
Molecular Weight:
300.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
off-white to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
InChI key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
Biochem/physiol Actions
GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.
Selective allosteric inhibitor of PARP14 macrodomain 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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