SML2267
GeA-69
≥98% (HPLC)
Synonym(s):
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
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About This Item
Empirical Formula (Hill Notation):
C20H16N2O
CAS Number:
Molecular Weight:
300.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
InChI key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
SMILES string
CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
assay
≥98% (HPLC)
form
powder
color
off-white to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.
Selective allosteric inhibitor of PARP14 macrodomain 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Marion Schuller et al.
ACS chemical biology, 12(11), 2866-2874 (2017-10-11)
Macrodomains are conserved protein interaction modules that can be found in all domains of life including in certain viruses. Macrodomains mediate recognition of sequence motifs harboring adenosine diphosphate ribose (ADPR) modifications, thereby regulating a variety of cellular processes. Due to
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