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SML2288

Anidulafungin

Name: Anidulafungin
Brand: SIGMA

≥97% (HPLC), powder, cell wall synthesis inhibitor

Synonym(s):

1-[(4R,5R)-4,5-Dihydroxy-N2-[[4′′-(pentyloxy)[1,1′:4′,1′′-terphenyl]-4-yl]carbonyl]-L-ornithine]echinocandin B, LY 303366

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About This Item

Empirical Formula (Hill Notation):

C₅₈H₇₃N₇O₁₇

CAS Number:

166663-25-8

Molecular Weight:

1140.24

NACRES:

NA.77

UNSPSC Code:

51111800

MDL number:

MFCD00917070

Assay:

≥97% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Anidulafungin, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCOC1=CC=C(C2=CC=C(C3=CC=C(C(N[C@H]4C[C@@H](O)[C@@H](O)NC([C@@H]5[C@@H](O)[C@@H](C)CN5C([C@H]([C@H](O)C)NC([C@H]([C@H](O)[C@@H](O)C6=CC=C(O)C=C6)NC([C@@H]7C[C@@H](O)CN7C([C@H]([C@H](O)C)NC4=O)=O)=O)=O)=O)=O)=O)C=C3)C=C2)C=C1

InChI

1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1

InChI key

JHVAMHSQVVQIOT-MFAJLEFUSA-N

Description

Application

Anidulafungin has been used as an internal positive inhibitor control in antifungal minimum inhibitory concentration (MIC) assay. It has also been used as an antifungal drug in disk diffusion assay to study drug resistance and tolerance in Candida spp.

Biochem/physiol Actions

Anidulafungin contains an alkoxytriphenyl chain, which may contribute to its anti-fungal activity. Anidulafungin may exhibit therapeutic effect against oesophageal and invasive candidiasis.

Anidulafungin is a semisynthetic echinocandin antifungal. Anidulafungin works by inhibiting the enzyme β(1,3)-D-Glucan synthase and thereby disturbing the integrity of the fungal cell wall. This enzyme does not exist in mammalian systems.

Semisynthetic echinocandin antifungal that inhibits 1,3-β-D-glucan synthase which is required for cell wall synthesis.

pictograms

GHS08

signalword

Warning

hcodes

H373

pcodes

P260 - P314 - P501

Hazard Classifications

STOT RE 2

target_organs

Liver

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000548914

0000548934