SML2300
ADA-07
≥95% (HPLC)
Synonym(s):
5-(adamantan-1-yl)-3-(hydroxyimino) indolin-2-one
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About This Item
Empirical Formula (Hill Notation):
C18H20N2O2
CAS Number:
Molecular Weight:
296.36
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
O=C(/C1=N\O)NC(C1=C2)=CC=C2C34C[C@@H](C5)C[C@@H](C[C@@H]5C4)C3
assay
≥95% (HPLC)
form
powder
color
yellow to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ADA-07 is a potent and selective T-LAK cell-originated protein kinase (TOPK) inhibitor that binds to ATP-binding pocket. ADA-07 suppresses SUV-induced phosphorylation of ERK1/2, p38, and JNKs and subsequently inhibited AP-1 activity, and reduces SUV-induced skin carcinogenesis.
potent and selective TOPK inhibitor that binds to ATP-binding pocket; reduces SUV-induced skin carcinogenesis
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ge Gao et al.
Molecular cancer therapeutics, 16(9), 1843-1854 (2017-06-29)
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK
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