SML2327
AA147
≥98% (HPLC)
Synonym(s):
N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide
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About This Item
Empirical Formula (Hill Notation):
C16H17NO2
CAS Number:
Molecular Weight:
255.31
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1=CC(C)=CC=C1O)CCC2=CC=CC=C2
Biochem/physiol Actions
AA147 is an ATF6α (ATF6) pathway-selective ER proteostasis network (PN) regulator (63.3% ATF6 vs.17.5% IRE1 activation, respectively, by HEK293-based ERSE- or XBP1s-luciferase reporter assay; 6.8 μM, 18 h) that selectively activates ATF6 target transcripts production over those of XBP1s & PERK (10 μM; HEK293T-Rex cells), inducing BiP mRNA in HepG2 and wt, but not Atf6-/-, MEFs (10 μM). AA147 enhances degradation and ER retention of destablized amyloidogenic transthyretin TTR(A25T) and Ig LC, respectively, exogenously expressed in HepG2 and ALMC-2. ATF6 activation by AA147 is also reported to suppress hESCs pluripotency and promotes mesodermal differentiation.
ATF6α-selective activator that reduces the secretion of destablized amyloidogenic proteins and promotes hESCs mesodermal differentiation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Lars Plate et al.
eLife, 5 (2016-07-21)
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UPR)-associated transcription factor ATF6 attenuates secretion
Heike Kroeger et al.
Science signaling, 11(517) (2018-02-15)
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β
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