SML2329
RP22
≥98% (HPLC)
Synonym(s):
AA147 Inactive Control, AA147 Negative Control, N-(2-Hydroxy-5-(trifluoromethyl)phenyl)-3-phenylpropanamide, N-[2-hydroxy-5-(trifluoromethyl)phenyl]-benzenepropanamide
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About This Item
Empirical Formula (Hill Notation):
C16H14F3NO2
CAS Number:
Molecular Weight:
309.28
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
O=C(NC1=CC(C(F)(F)F)=CC=C1O)CCC2=CC=CC=C2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Inactive analog of the ATF6α-selective activator AA147.
RP22 is a AA147 analog with no ATF6α-activating potency. RP22 is the recommended inactive control for AA147 in probing ATF6α signaling-mediated unfolded protein response (UPR).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Heike Kroeger et al.
Science signaling, 11(517) (2018-02-15)
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β
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