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Merck
CN

SML2329

Sigma-Aldrich

RP22

≥98% (HPLC)

Synonym(s):

AA147 Inactive Control, AA147 Negative Control, N-(2-Hydroxy-5-(trifluoromethyl)phenyl)-3-phenylpropanamide, N-[2-hydroxy-5-(trifluoromethyl)phenyl]-benzenepropanamide

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About This Item

Empirical Formula (Hill Notation):
C16H14F3NO2
CAS Number:
2102925-19-7
Molecular Weight:
309.28
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC(C(F)(F)F)=CC=C1O)CCC2=CC=CC=C2

Biochem/physiol Actions

Inactive analog of the ATF6α-selective activator AA147.
RP22 is a AA147 analog with no ATF6α-activating potency. RP22 is the recommended inactive control for AA147 in probing ATF6α signaling-mediated unfolded protein response (UPR).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000049062
0000049063
0000041633

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Heike Kroeger et al.
Science signaling, 11(517) (2018-02-15)
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β

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