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Merck
CN

SML2337

Diasarone-I

≥98% (HPLC)

Synonym(s):

(E)-3-ethyl-2-methyl-3-(2′′,4′′,5′′-trimethoxy)phenyl-1-(2′,4′,5′-trimethoxy)phenyl-1-propene, 1,1′-[(1E)-3-Ethyl-2-methyl-1-propene-1,3-diyl]bis[2,4,5-trimethoxybenzene], Diasarone 1, Diasarone I, NEOLASA-I

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About This Item

Empirical Formula (Hill Notation):
C24H32O6
CAS Number:
80423-94-5
Molecular Weight:
416.51
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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InChI

1S/C24H32O6/c1-9-17(18-12-22(28-6)24(30-8)14-20(18)26-4)15(2)10-16-11-21(27-5)23(29-7)13-19(16)25-3/h10-14,17H,9H2,1-8H3/b15-10+

InChI key

GGIJVVURVQQPBB-XNTDXEJSSA-N

SMILES string

C/C(C(CC)C1=CC(OC)=C(OC)C=C1OC)=C\C2=C(OC)C=C(OC)C(OC)=C2

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds to the viral 2′O methyltransferase of nonstructural protein 5 (NS5). It also decreases the DENV2-induced STAT1 phosphorylation and IFN-stimulated genes (ISGs) expression.
The antiviral effect of Diasarone-I includes half maximal effective concentration (EC50) of 4.5 μM and half maximal cytotoxicity concentration (CC50) of >80 μM.
antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000059340
0000059341
0000053159

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Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
Yao X, et al.
European Journal of Pharmacology, 821, 11-20 (2018)
Xingang Yao et al.
European journal of pharmacology, 821, 11-20 (2017-12-17)
Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing

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