SML2371
FC-99 hydrochloride
≥98% (HPLC)
Synonym(s):
FC 99 hydrochloride, FC99 hydrochloride, N1-[(4-Methoxyphenyl)methyl]-4-methyl-1,2-benzenediamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C15H18N2O · xHCl
CAS Number:
Molecular Weight:
242.32 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC1=CC(N)=C(C=C1)NCC2=CC=C(C=C2)OC
InChI
1S/C15H18N2O/c1-11-3-8-15(14(16)9-11)17-10-12-4-6-13(18-2)7-5-12/h3-9,17H,10,16H2,1-2H3
InChI key
ZPNPYWSZYRMBNP-UHFFFAOYSA-N
Biochem/physiol Actions
FC-99 is known to affect the levels of serum immunoglobulin. It might be therapeutically beneficial in systemic lupus erythematosus.
FC-99 is a benzenediamine derivative that inhibits LPS-induced IRAK4 phosphorylation/activation and downstream signaling events (5-45 μM; murine RAW 264.7 & peritoneal macrophages), including IRAK1 (a TLR3 pathway negative regulator) degradation, p38/ERK/JNK activation, and cytokines production. FC-99 inhibits RSV replication (50 μM; A549) and poly(I:C)-indued IRF3/IFN-α/JAK/STAT1 signalling in cultures (0.5-50 μM; murine peritoneal macrophages), and ameliorates sepsis induction following caecal ligation puncture (CLP) in mice in vivo (100/70/32.5% motality in 7 days with 0/30/100 mg/kg i.p. 2 h prior to CLP).
IRAK4 activation and IRAK1 degradation inhibitor that suppresses toll-like receptors (TLRs) cellular signaling and ameliorates sepsis induction in mice in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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