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SML2397

Dooku1

Name: Dooku1
Brand: SIGMA

≥98% (HPLC), eIF4E inhibitor, powder

Synonym(s):

2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₉Cl₂N₃OS

CAS Number:

2253744-54-4

Molecular Weight:

326.20

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Dooku1, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2

InChI

1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2

InChI key

MNPOBXLPCWFONX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.

potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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