SML2400
LW106
>97% (HPLC)
Synonym(s):
(4-Amino-1,2,5-oxadiazol-3-yl)(1,3-dihydro-2H-isoindol-2-yl)-methanone oxime, (E)-(4-Amino-1,2,5-oxadiazol-3-yl)(isoindolin-2-yl)methanone oxime
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C11H11N5O2
CAS Number:
Molecular Weight:
245.24
UNSPSC Code:
12352200
SMILES string
O/N=C(C1=NON=C1N)/N2CC3=CC=CC=C3C2
assay
>97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Indoleamine 2,3-dioxygenase 1 (IDO; IDO1) inhibitor with better in vivo antitumor efficacy than Epacadostat (INCB024360).
LW106 is an indoleamine 2,3-dioxygenase 1 (IDO; IDO1) inhibitor (IC50 = 13 nM) that effectively inhibits kynurenine production upon cellular IDO1 upregulation by IFNγ induction (50 ng/mL, 48 h) in HeLa cultures (IC50 = 1.57 μM) and prevents the antiproliferation activity of IDO1-positive DCs against co-cultured CD8+ T-cells (proliferation suppression = 67% with vehicle vs. 33% with 20 μM LW106). LW106 exhibits antitumor activity only in immunocompetent, but not athymic or IDO1-/-, mice, displaying better in vivo efficacy than Epacadostat (Lewis lung carcinoma/B16-F10 tumor suppression = 68%/65% with LW106 vs. 51%/50% with Epacadostat; 80 mg/kg/day i.p.).
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Rong Fu et al.
British journal of pharmacology, 175(14), 3034-3049 (2018-05-04)
Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as an important new therapeutic target for treatment of malignant tumours characterized by dysregulated tryptophan metabolism. However, the antitumour efficacy of existing small-molecule inhibitors of IDO1 is still unsatisfactory and the underlying mechanism remains
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service