SML2544
NSC49652
≥98% (HPLC)
Synonym(s):
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one, (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
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About This Item
Empirical Formula (Hill Notation):
C14H11NO2
CAS Number:
Molecular Weight:
225.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O
InChI
1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
InChI key
CRWNZUBUBIULHB-BQYQJAHWSA-N
Biochem/physiol Actions
NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.
orally active, potent and selective inhibitor of death receptor p75NTR that targets the interfaces between transmembrane domains
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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