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SML2623

(+)-JQ-1 carboxylic acid

≥95% (HPLC)

Synonym(s):

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, (S)-[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-yl]acetic acid, 2-[(6S,Z)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid

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About This Item

Empirical Formula (Hill Notation):
C19H17ClN4O2S
CAS Number:
202592-23-2
Molecular Weight:
400.88
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
MFCD28167916
Assay:
≥95% (HPLC)
Form:
powder
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assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[s]1c2c(c(c1C)C)C(=N[C@H](c4[n]2c(nn4)C)CC(=O)O)c3ccc(cc3)Cl

InChI

1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1

InChI key

LJOSBOOJFIRCSO-AWEZNQCLSA-N

Biochem/physiol Actions

(+)-JQ-1 carboxylic acid is a potent BET (bromodomain and extra terminal domain) inhibitor. (+)-JQ-1 carboxylic acid could serve as precursor to synthesize PROTACs and other conjugates.
potent BET inhibitor; precursor to synthesize PROTACs

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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