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SML2723

NVS-ZP7-4

≥98% (HPLC)

Synonym(s):

(S)-1-(2-((6-fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1′H-spiro[piperidine-4,4′-quinazolin]-2′(3′H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-spiro[piperidine-4,4′(1′H)-quinazolin]-2′(3′H)-one

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About This Item

Empirical Formula (Hill Notation):
C28H28FN5OS
CAS Number:
2349367-89-9
Molecular Weight:
501.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD31813751
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1cc2[s]c(nc2cc1)N[C@H](CN4CCC5(NC(=O)Nc6c5cccc6)CC4)Cc3ccccc3

InChI

1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1

InChI key

FZOFDZMKSAUTHT-NRFANRHFSA-N

Biochem/physiol Actions

NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels.
potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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