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SML2746

SRS11-92

≥98% (HPLC)

Synonym(s):

4-(Cyclohexylamino)-3-[(phenylmethyl)amino]-benzoic acid ethyl ester, Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate

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About This Item

Empirical Formula (Hill Notation):
C22H28N2O2
CAS Number:
Molecular Weight:
352.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to yellow-brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(C3CCCCC3)c1c(cc(cc1)C(=O)OCC)NCc2ccccc2

InChI key

VHQAJFNLPQULSV-UHFFFAOYSA-N

Biochem/physiol Actions

SRS11-92 is a cell penetrant and potent inhibitor of ferroptosis that attenuates the cell death associated with frataxin knockdown in healthy human fibroblasts. SRS11-92 protects against cell death in in a brain slice model of Huntington′s disease, an oligodendrocyte model of periventricular leukomalacia, and in isolated kidney proximal tubules model of kidney disfunction.
cell penetrant and potent inhibitor of ferroptosis that attenuates the cell death associated with frataxin knockdown in healthy human fibroblasts


Storage Class

11 - Combustible Solids

wgk

WGK 3



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