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SML2798

CH625

≥98% (HPLC)

Synonym(s):

(2E)-1-(4-Hydroxy-2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,4′-Dihydroxy-2′,6′-dimethoxychalcone, ZINC95910725

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About This Item

Empirical Formula (Hill Notation):
C17H16O5
CAS Number:
123316-64-3
Molecular Weight:
300.31
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

CH625 is a potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in glioma intracranial and subcutaneous model in rats. CH625 normalizes tumor vasculature in the C6 and GL261 gliomas through tumor-associated macrophages (TAMs) reprograming and inhibition of VEGF and TGF-β production.
potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in gliomas

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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