SML2894
HPA-12
≥98% (HPLC), Cer transporter (CERT) antagonist, powder
Synonym(s):
(1R,3S)-HPA-12, (1R,3S)-N-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide, 16ASC1859, N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide, N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide
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About This Item
Empirical Formula (Hill Notation):
C22H37NO3
CAS Number:
Molecular Weight:
363.53
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
HPA-12, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
N([C@@H](CO)C[C@H](O)c1ccccc1)C(=O)CCCCCCCCCCC
InChI
1S/C22H37NO3/c1-2-3-4-5-6-7-8-9-13-16-22(26)23-20(18-24)17-21(25)19-14-11-10-12-15-19/h10-12,14-15,20-21,24-25H,2-9,13,16-18H2,1H3,(H,23,26)/t20-,21+/m1/s1
InChI key
YCAKBKAOFSILDC-RTWAWAEBSA-N
Biochem/physiol Actions
(1R,3S)-HPA-12 is a ceramide (Cer) analog that acts as a Cer transporter (CERT) antagonist and selectively inhibits cellular Cer conversion to sphingomyelin (SM), but not to glucosylceramide, by blocking CERT-mediated Cer ER-to-Golgi transport. Common culture dosing range: 1-10 μM.
Ceramide transporter (CERT) antagonist that inhibits Cer-to-sphingomyelin (SM) conversion by blocking CERT-mediated ceramide ER-to-Golgi transport.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2894-25MG | 04061842604388 |
| SML2894-5MG | 04061842604395 |