SML2907
Azumolene
≥98% (HPLC)
Synonym(s):
1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione, EU 4093
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About This Item
Empirical Formula (Hill Notation):
C13H9BrN4O3
CAS Number:
Molecular Weight:
349.14
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)
InChI key
SEGCNGONCZQFDW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to very dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Azumolene, a more water-soluble analog of dantrolene, is a potent inhibitor of sarcoplasmic reticulum (SR) ryanodine receptor (RyR) that inhibits skeletal muscle SR Ca2+ release. Azumolene is a direct acting skeletal muscle relaxant that induces effective blockade of skeletal muscle RyR1.
potent inhibitor of sarcoplasmic reticulum ryanodine receptor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Erin E Talbert et al.
PloS one, 11(2), e0148161-e0148161 (2016-02-06)
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to protect
Yingfan Zhang et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 94-102 (2005-04-16)
Azumolene is an analog of dantrolene, the only approved medicine for treatment of malignant hyperthermia (MH). The pharmacological mechanism of these drugs is to inhibit skeletal muscle sarcoplasmic reticulum (SR) Ca2+ release by modulating the activity of the SR ryanodine
Daoyuan Si et al.
Journal of cardiovascular electrophysiology, 29(12), 1707-1715 (2018-09-12)
Following long-duration ventricular fibrillation (LDVF), reinitiation of ventricular fibrillation (VF) poses a major challenge during resuscitation. Ryanodine receptor 2 (RyR2) becomes dysfunctional following VF. The relationship between LDVF, RyR2 modulation, and ventricular refibrillation, as well as the role of RyR2 phosphorylation
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