SML2909
Nolatrexed dihydrochloride
≥98% (HPLC)
Synonym(s):
2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride, AG 337
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About This Item
Empirical Formula (Hill Notation):
C14H12N4OS · 2HCl
CAS Number:
Molecular Weight:
357.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O
InChI
1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
InChI key
PJKVJJYMWOCLIJ-UHFFFAOYSA-N
Biochem/physiol Actions
Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.
potent thymidylate synthase inhibitor
signalword
Warning
hcodes
Hazard Classifications
Muta. 2 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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