SML2962
MM07 trifluoroacetate
≥94.5% (HPLC)
Synonym(s):
Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe disulfide bridge 1-6 trifluoroacetate, L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-histidyl-L-lysyl-glycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine (1->6)-disulfide trifluoroacetate, cyclo[1-6]CRPRLCHKGPMPF trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C67H106N22O14S3
Molecular Weight:
1539.89
NACRES:
NA.77
UNSPSC Code:
12352200
Biochem/physiol Actions
G protein biased apelin receptor agonist
MM07 is a G protein biased apelin receptor agonist that causes rapid and significant peripheral arterial dilatation in human hand vein. MM07 is more stable than the endogenous apelin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Sahori Yamazaki et al.
Scientific reports, 10(1), 1349-1349 (2020-01-30)
Several studies have demonstrated potential roles for apelin/APJ signaling in the regulation of oxidative stress associated with ischemia-reperfusion (I/R) injury in several organs. Objective was to assess the role of apelin/APJ signaling in the development of pressure ulcers (PUs) formation
Aimee L Brame et al.
Hypertension (Dallas, Tex. : 1979), 65(4), 834-840 (2015-02-26)
[Pyr(1)]apelin-13 is an endogenous vasodilator and inotrope but is downregulated in pulmonary hypertension and heart failure, making the apelin receptor an attractive therapeutic target. Agonists acting at the same G-protein-coupled receptor can be engineered to stabilize different conformational states and
Peiran Yang et al.
British journal of pharmacology, 176(9), 1206-1221 (2019-02-03)
Apelin is an endogenous vasodilatory and inotropic peptide that is down-regulated in human pulmonary arterial hypertension, although the density of the apelin receptor is not significantly attenuated. We hypothesised that a G protein-biased apelin analogue MM07, which is more stable
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