SML3078
JT003 trifluoroacetate
≥95% (HPLC)
Synonym(s):
P-Nva-LYYFA trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C46H62N8O9 · xC2HF3O2
Molecular Weight:
871.03 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
assay
≥95% (HPLC)
form
film or powder
color
white to off-white
storage temp.
−20°C
Related Categories
Biochem/physiol Actions
JT003 is potent dual agonist of adiponectin receptors AdipoR1/AdipoR2 that potently improves insulin resistance in high fat diet induced nonalcoholic steatohepatitis (NASH) mice. JT003 inhibits hepatic stellate cells (HSCs) activation in CCl4 induced liver fibrosis.
potent dual agonist of adiponectin receptors AdipoR1/AdipoR2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Michishige Terasaki et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are
Hongjiao Xu et al.
Nature communications, 11(1), 5807-5807 (2020-11-18)
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs
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