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Merck
CN

SML3134

Sigma-Aldrich

Tabernanthalog fumarate

≥98% (HPLC)

Synonym(s):

1,2,3,4,5,6-Hexahydro-8-methoxy-3-methyl-azepino[4,5-b]indole fumarate, 8-Methoxy-3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate, TBG fumarate

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O · C4H4O4
CAS Number:
2483829-59-8
Molecular Weight:
346.38
UNSPSC Code:
12352200

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(O)/C=C/C(O)=O.CN1CCC(NC2=C3C=CC(OC)=C2)=C3CC1

Biochem/physiol Actions

Tabernanthalog (TBG) is a water-soluble, non-hallucinogenic and non-toxic ibogaine analog with potent 5-HT2A receptor (human and mouse) agonist and 5-HT2B receptor (human) antagonist activities, but no opioid agonist activity.TBG induces rat dendritic growth blockable by the 5-HT2A antagonist ketanserin in cultures and exhibits antidepressant-like efficacy in vivo (50 mg/kg via i.p. by mouse forced swimming or alcohol consumption, 40 mg/kg by rat heroin self-administration).
Water-soluble, non-hallucinogenic, non-toxic ibogaine analog with 5-HT2A agonist and 5-HT2B antagonist potency, and in vivo antidepressant-like efficacy.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000189712
0000189712
0000141185

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