SML3164
CAM833
≥98% (HPLC)
Synonym(s):
CAM833A, N-(2-((2S,4R)-2-(((S)-1-(2-chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C26H26ClFN4O5
Molecular Weight:
528.96
UNSPSC Code:
12352107
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=C(N=C(C(NCC(N2[C@H](C(N[C@H](C3=C(Cl)C=C(OC)C=C3)C)=O)C[C@@H](O)C2)=O)=O)C=C4)C4=C1
InChI key
PMUWBFKMLGLUTF-KNUWZQJKSA-N
Biochem/physiol Actions
CAM833 is a potent and selective inhibitor of RAD51:BRCA2 interaction that inhibits RAD51 foci formation in A549 non-small cell lung carcinoma (NSCLC) cells. CAM833 suppresses extended RAD51 filament assembly. It potentiates the DNA damage by ionizing radiation in cells.
potent and selective inhibitor of RAD51:BRCA2 interaction
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Duncan E Scott et al.
Cell chemical biology, 28(6), 835-847 (2021-03-05)
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a monomeric thermostable chimera between human RAD51 and archaeal RadA, we
Duncan E Scott et al.
Cell chemical biology, 28(6), 835-847 (2021-03-05)
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a monomeric thermostable chimera between human RAD51 and archaeal RadA, we
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