SML3178
CPS2
≥98% (HPLC)
Synonym(s):
4-((5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)-N-(2-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C38H42N12O10S2
CAS Number:
Molecular Weight:
890.94
NACRES:
NA.77
UNSPSC Code:
12352107
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
General description
CPS2 is derived from JNJ-7706621 which is a CDK/aurora inhibitor. It exhibits anti-proliferative effects.
Biochem/physiol Actions
CPS2 is a cell penetrant proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2). CPS2 potently degrades CDK2 in different cell lines. It appears that it does not induce comparable degradation of other targets
cell penetrant and selective proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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