SML3178
CPS2
≥98% (HPLC)
Synonym(s):
4-((5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)-N-(2-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C38H42N12O10S2
CAS Number:
Molecular Weight:
890.94
NACRES:
NA.77
UNSPSC Code:
12352107
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
General description
CPS2 is derived from JNJ-7706621 which is a CDK/aurora inhibitor. It exhibits anti-proliferative effects.
Biochem/physiol Actions
CPS2 is a cell penetrant proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2). CPS2 potently degrades CDK2 in different cell lines. It appears that it does not induce comparable degradation of other targets
cell penetrant and selective proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts
Zhouling Xie, et al.
European Journal of Medicinal Chemistry, 6356?6389-6356?6389 (2022)
Liguo Wang et al.
Nature chemical biology, 17(5), 567-575 (2021-03-06)
The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the differentiation arrest of acute myeloid leukemia (AML) cells, may be a promising method for
Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon
Andrea G L, et al.
Molecules (Basel), 28(3), 1224-1224 (2023)
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