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Merck
CN

SML3178

Sigma-Aldrich

CPS2

≥98% (HPLC)

Synonym(s):

4-((5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)-N-(2-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C38H42N12O10S2
CAS Number:
2756741-90-7
Molecular Weight:
890.94
UNSPSC Code:
12352107
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

General description

CPS2 is derived from JNJ-7706621 which is a CDK/aurora inhibitor. It exhibits anti-proliferative effects.

Biochem/physiol Actions

CPS2 is a cell penetrant proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2). CPS2 potently degrades CDK2 in different cell lines. It appears that it does not induce comparable degradation of other targets
cell penetrant and selective proteolysis-targeting chimera (PROTAC) that targets cyclin-dependent kinase 2 (CDK2)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000157012
0000157011
0000157012
0000144023
0000144023

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Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts
Zhouling Xie, et al.
European Journal of Medicinal Chemistry, 6356?6389-6356?6389 (2022)
Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon
Andrea G L, et al.
Molecules (Basel), 28(3), 1224-1224 (2023)
Liguo Wang et al.
Nature chemical biology, 17(5), 567-575 (2021-03-06)
The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the differentiation arrest of acute myeloid leukemia (AML) cells, may be a promising method for

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