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Merck
CN

SML3282

Sigma-Aldrich

HS-1371 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline trifluoroacetate salt, 7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline trifluoroacetate salt, HS 1371, HS1371

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About This Item

MDL number:
MFCD31813738
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, White to very dark gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C=C1)=CC=C1OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23

InChI

1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3

InChI key

VPVLPCIBKVWFDT-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

HS-1371 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 20.8 nM, [ATP] = 10 μM) that blocks RIP3 S227 autophosphorylation and selectively suppresses TNF/SMAC mimetic/Z-VAD-FMK agonist treatment-induced necroptosis induction in HT-29 cultures (by 44.4% at 1 μM, by 77.7% at 5 μM) in a RIP3- and MLKL-dependent manner.
Potent ATP-competitive RIP3 (RIPK3) kinase inhibitor that suppresses necroptosis in a RIP3- and MLKL-dependent manner.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000201236
0000201235
0000186690
0000186690
0000201236

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Jiayu Zhang et al.
Oncogene, 40(29), 4783-4795 (2021-06-23)
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among breast tumors and remains a challenge even for the most current therapeutic regimes. Here, we demonstrate that oncolytic alphavirus M1 effectively kills both TNBC and non-TNBC. ER-stress and apoptosis
Han-Hee Park et al.
Experimental & molecular medicine, 50(9), 1-15 (2018-09-22)
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity is essential for downstream necroptotic signaling events. Since RIP3 kinase
Jimin Jeon et al.
Annals of the rheumatic diseases, 79(12), 1635-1643 (2020-09-09)
Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal role in necroptosis and its dysregulation is involved in various

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