SML3287
Sulfopin
≥98% (HPLC)
别名:
2-Chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-acetamide
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关于此项目
经验公式（希尔记法）:
C11H20ClNO3S
化学文摘社编号:
分子量:
281.80
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
InChI
1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
InChI key
NMHVAHHYKGXBMY-UHFFFAOYSA-N
Biochem/physiol Actions
In vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1)
Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable