SML3287
Sulfopin
≥98% (HPLC)
Synonym(s):
2-Chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-acetamide
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About This Item
Empirical Formula (Hill Notation):
C11H20ClNO3S
CAS Number:
Molecular Weight:
281.80
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
InChI
1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
InChI key
NMHVAHHYKGXBMY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
In vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1)
Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Christian Dubiella et al.
Nature chemical biology, 17(9), 954-963 (2021-05-12)
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library to identify covalent inhibitors targeting Pin1's active
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