SML3333
Dianhydrogalactitol
≥95% (HPLC)
Synonym(s):
1,2:5,6-Dianhydrogalactitol, 1,2:5,6-Diepoxydulcitol, DAG, NSC-132313, VAL-083
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About This Item
Empirical Formula (Hill Notation):
C6H10O4
CAS Number:
Molecular Weight:
146.14
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O[C@H]([C@@]1(CO1)[H])[C@H]([C@]2(CO2)[H])O
InChI
1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
InChI key
AAFJXZWCNVJTMK-GUCUJZIJSA-N
Biochem/physiol Actions
Blood brain barrier penetrant alkylating agent that causes N7-guanine alkylation
Dianhydrogalactitol is a blood brain barrier penetrant and potent alkylating agent that causes N7-guanine alkylation and inter-strand DNA crosslinks that induces cell cycle arrest followed by apoptosis. Dianhydrogalactitol exhibits potent antitumor activity in number of clinical models including metastatic NSCLC resistant to TKI and glioblastoma multiforme.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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