SML3333
Dianhydrogalactitol
≥95% (HPLC)
Synonym(s):
1,2:5,6-Dianhydrogalactitol, 1,2:5,6-Diepoxydulcitol, DAG, NSC-132313, VAL-083
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About This Item
Empirical Formula (Hill Notation):
C6H10O4
CAS Number:
Molecular Weight:
146.14
MDL number:
UNSPSC Code:
12352200
Quality Level
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O[C@H]([C@@]1(CO1)[H])[C@H]([C@]2(CO2)[H])O
InChI
1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2/t3-,4+,5+,6-
InChI key
AAFJXZWCNVJTMK-GUCUJZIJSA-N
Related Categories
Biochem/physiol Actions
Blood brain barrier penetrant alkylating agent that causes N7-guanine alkylation
Dianhydrogalactitol is a blood brain barrier penetrant and potent alkylating agent that causes N7-guanine alkylation and inter-strand DNA crosslinks that induces cell cycle arrest followed by apoptosis. Dianhydrogalactitol exhibits potent antitumor activity in number of clinical models including metastatic NSCLC resistant to TKI and glioblastoma multiforme.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Chun Peng et al.
Acta pharmacologica Sinica, 38(4), 561-570 (2017-02-22)
1,2:5,6-dianhydrogalactitol (DAG) is a hexitol epoxide with marked antitumor activity against multiple types of cancer cells, but the molecular mechanisms by which DAG functions as an antitumor agent is largely unknown. In this study, we investigated the inhibitory effects of
Xia Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 91, 1065-1074 (2017-05-21)
The complexity of cancer has led to single-target agents exhibiting lower-than-desired clinical efficacy. Drugs with multiple targets provide a feasible option for the treatment of complex tumors. Multitarget anti-angiogenesis agents are among the new generation of anticancer drugs and have
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