SML3462
IAXO-102 trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
IAXO 102 trifluoroacetate salt, Methyl 6-deoxy-6-amino-2,3-di-O-tetradecyl-α-D-glucopyranoside trifluoroacetate salt
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
Empirical Formula (Hill Notation):
C35H71NO5 · xC2HF3O2
Molecular Weight:
585.94 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
storage temp.
-10 to -25°C
SMILES string
O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]1CN)OC)OCCCCCCCCCCCCCC)OCCCCCCCCCCCCCC.[xCF3CO2H]
Related Categories
Biochem/physiol Actions
IAXO-102 is a potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock. IAXO-102 inhibits development of an experimental abdominal aortic aneurysm. It also prevents acute BBB disruption after experimental post-subarachnoid hemorrhage in mice.
Potent and selective toll-like receptor 4 (TLR4) antagonist that protect mice from LPS induced septic shock.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development.
Huggins C, Pearce S, Peri F, Neumann F, Cockerill G, Pirianov G.
Atherosclerosis (2015)
Selective Toll-Like Receptor 4 Antagonists Prevent Acute Blood-Brain Barrier Disruption After Subarachnoid Hemorrhage in Mice.
Okada T, Kawakita F, Nishikawa H, Nakano F, Liu L, Suzuki H.
Molecular Neurobiology (2019)
Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization.
Piazza M, Rossini C, Della Fiorentina S, Pozzi C, Comelli F, Bettoni I, Fusi P, Costa B, Peri F.
Journal of Medicinal Chemistry (2009)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service