SML3488
CuATSP
≥98% (HPLC)
Synonym(s):
(SP-4-2)-[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-phenylhydrazinecarbothioamidato-κN2,κS]](2-)]copper, Cu ATSP, Cu-ATSP
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About This Item
Empirical Formula (Hill Notation):
C18H18CuN6S2
CAS Number:
Molecular Weight:
446.05
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
CC1=[N]2[Cu]3(SC(NC4=CC=CC=C4)=N2)SC(NC5=CC=CC=C5)=N[N]3=C1C
assay
≥98% (HPLC)
form
powder
color
, Faint brown to dark red
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency.
CuATSP is a CuATSM analog with >10-fold enhanced ferropotosis inhibitory potency (CuATSP/CuATSM IC50 against 150 nM RSL3-induced ferroptosis = 8.5/160 nM using Pfa1 mouse embryonic fibroblasts,16/170 nM using HT-22 mouse hippocampal cells). CuATSP and CuATSM exert their radical-trapping antioxidant (RTA) and (phospho)lipid peroxidation inhibitory potency via an initial reversible addition of a peroxyl radical to the bis(thiosemicarbazone) ligand, followed by a subsequent H-atom transfer (HAT) that drives the reaction forward.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death.
Zilka O, Poon JF, Pratt DA
Journal of the American Chemical Society, 143, 19043-19057 (2021)
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