SML3498
L6H21
≥98% (HPLC)
别名:
(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one, (E)-2,3,4′-Trimethoxy-chalcone, (E)-2,3-Dimethoxy-4′-methoxychalcone, L 6H21
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C18H18O4
化学文摘社编号:
分子量:
298.33
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
L6H21 is an orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist and shows a great inhibitory effect on pro-inflammatory cytokines expression levels. L6H21 binds to the hydrophobic pocket of MD2 in a dose-dependent manner with a high affinity (Kd = 33.3 µM) and inhibits the ability of LPS to recognize TLR4/MD2 complex. Suppresses NLRP3 inflammasome activation and may serve as a potential candidate for the treatment of allograft rejection.
Orally bioavailable chalcone that acts as a myeloid differentiation factor 2 (MD2) antagonist
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable