SML3585
PSB-CB5
≥98% (HPLC)
Synonym(s):
5H-Imidazo[2,1-b][1,3]thiazin-3(2H)-one, 2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-, (2Z)
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About This Item
Empirical Formula (Hill Notation):
C20H17ClN2O2S
CAS Number:
Molecular Weight:
384.88
UNSPSC Code:
51111800
NACRES:
NA.21
InChI key
XJBQRMOGMULGPP-PDGQHHTCSA-N
SMILES string
O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PSB-CB5 is a potent and selective GPR18 antagonist that inhibits Δ9-THC-induced GPR18 β-arrestin recruitment (IC50 = 279 nM; [THC] = EC50 = 7.5 μM) with no potency against human GPR55 (IC50 >10 μM) and little or no affinity toward human CB2 and CB1 (Ki = 4.03 μM & >10 μM, respectively).
Potent and selective GPR18 antagonist with little or no potency towrd human GPR55, CB1 or CB2.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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