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Merck
CN

SML3600

AZ10606120 dihydrochloride

≥98% (HPLC)

Synonym(s):

2-(1-Adamantyl)-N-[2-({2-[(2-hydroxyethyl)amino]ethyl}amino)quinolin-5-yl]acetamide dihydrochloride, AZ 10606120 dihydrochloride, AZ-10606120 dihydrochloride, Compound-17 dihydrochloride, N-[2-({2-[(2-Hydroxyethyl)amino]ethyl}amino)-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidee dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C25H34N4O2·2HCl
CAS Number:
607378-18-7
Molecular Weight:
495.48
UNSPSC Code:
51111800
NACRES:
NA.04

Key Documents

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SMILES string

O=C(NC1=CC=CC2=C1C=CC(NCCNCCO)=N2)CC3(C[C@H]4C5)C[C@@H](C4)C[C@@H]5C3.[2HCl]

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light, under inert gas

color

white to beige

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

AZ-10606120 is a potent purinoceptor P2X7 negative allosteric modulator that antagonizes ATP-dependent P2X7 activation (IC50 against ATP-induced ethidium bromide uptake = 2.3 nM and 24 nM, respectively, using human or rat P2X7 HEK293 transfectants; [ATP] = EC50) in a non-competitive and slowly reversible manner via affinity interaction at an allosteric pocket (human/rat P2X7 KD = 1.4 nM/19 nM) distinct from the KN-62- or ATP-binding site. A useful tool for probing P2X7-mediated physiological and pathological processes both in cultures (0.1-10 µM) and in vivo (e.g. 5 mg/kg i.p., 300 nM i.m., or 3 µg i.c.v.; in mice).
Potent purinoceptor P2X7 negative allosteric modulator that antagonizes ATP-dependent P2X7 activation in a non-competitive and slowly reversible manner.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000225760
0000225759
0000225760
0000225759

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