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Merck
CN

SML3647

Sigma-Aldrich

Ulifloxacin

≥98% (HPLC)

Synonym(s):

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid, AF 3013, NAD 394, NM 394

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About This Item

Empirical Formula (Hill Notation):
C16H16FN3O3S
CAS Number:
112984-60-8
Molecular Weight:
349.38
MDL number:
MFCD00882994
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1cc2c(cc1N4CCNCC4)N3C(SC3=C(C2=O)C(=O)O)C

InChI

1S/C16H16FN3O3S/c1-8-20-11-7-12(19-4-2-18-3-5-19)10(17)6-9(11)14(21)13(16(22)23)15(20)24-8/h6-8,18H,2-5H2,1H3,(H,22,23)

InChI key

SUXQDLLXIBLQHW-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Orally available, broad-spectrum fluoroquinolone antibacterial agent that potently inhibits bacterial DNA gyrase and topoisomerase IV
Ulifloxacin is an orally available, broad-spectrum fluoroquinolone antibacterial agent. Ulifloxacin is an active metabolite of Prulifloxacin. It potently inhibits bacterial DNA gyrase and topoisomerase IV.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H315,H362,H373

Hazard Classifications

Lact. - Skin Irrit. 2 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000244476
0000244475
0000238751
0000244476
0000244475

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Susan J Keam et al.
Drugs, 64(19), 2221-2234 (2004-10-01)
Prulifloxacin, the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent. After absorption, prulifloxacin is metabolised by esterases to ulifloxacin. The drug has a long elimination half-life, allowing once-daily administration. Ulifloxacin is generally more active in vitro than other
Valeria Tellone et al.
Drugs in R&D, 18(3), 237-245 (2018-08-29)
The antibacterial agent prulifloxacin, a prodrug of ulifloxacin, is indicated in the treatment of acute lower urinary tract infections, acute exacerbation of chronic bronchitis and acute bacterial rhinosinusitis. We aimed to provide new insights on the pharmacokinetics (PK) of ulifloxacin
Marcello Locatelli et al.
Journal of enzyme inhibition and medicinal chemistry, 31(1), 106-111 (2015-02-17)
A new and specific HPLC-DAD method for the direct determination of Prulifloxacin and its active metabolite, Ulifloxacin, in human plasma has been developed. Plasma samples were analysed after a simple solid phase extraction (SPE) clean-up using a new HILIC stationary

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