SML3652
TASP0277308
≥98% (HPLC)
Synonym(s):
(R)-3,4-Dichloro-N-(1-(4-ethyl-5-(3-(4-methylpiperazin-1-yl)phenoxy)-4H-1,2,4-triazol-3-yl)ethyl)benzenesulfonamide, 3,4-Dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methyl-1-piperazinyl)phenoxy]-4H-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide, TASP 0277308, TASP-0277308
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About This Item
Empirical Formula (Hill Notation):
C23H28Cl2N6O3S
CAS Number:
Molecular Weight:
539.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Orally active, highly S1P1 subtype-selective sphingosine-1-phosphate (S1P) receptor antagonist with in vitro and in vivo efficacy.
TASP0277308 is an orally active, highly S1P1 subtype-selective sphingosine-1-phosphate (S1P) receptor antagonist (IC50 = 2.7/4.2 nM against 0.1 nM S1P for binding mouse/human S1P1; IC50 >8.7 μM for S1P2-5). TASP0277308 effectively inhibits S1P1-mediated GTPγS membrane binding, cAMP response and chemotaxis (IC50 = 7.8, 3.5, 15 nM, respectively, agianst 10 nM S1P; hS1P1-expressing HEK293 or CHO) and demonstrates in vivo efficacy in various animal disease models, including collagen-induced arthritis and tumor angiogenesis in mice (10-100 mg/kg bid po), as well as neuropathic pain in rats (0.6-3 mg/kg via acute po or ip, acute 30 nmol or daily 10 nmol intrathecal injection).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain
Proceedings of the National Academy of Sciences of the USA, 116(21), 10557-10562 (2019)
Amelioration of collagen-induced arthritis by a novel S1P1 antagonist with immunomodulatory activities
Journal of immunology (Baltimore, Md. : 1950), 188(1), 206-215 (2012)
Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation
Pain, 158(9), 1733-1742 (2017)
Luca Piali et al.
Pharmacology research & perspectives, 5(6) (2017-12-12)
Sphingosine-1-phosphate receptor 1 (S1P1 ) modulators sequester circulating lymphocytes within lymph nodes, thereby preventing potentially pathogenic autoimmune cells from exiting into the blood stream and reaching inflamed tissues. S1P1 receptor modulation may thus offer potential to treat various autoimmune diseases.
Sphingosine 1-Phosphate Receptor Subtype 1 as a Therapeutic Target for Brain Trauma
Journal of Neurotrauma, 35(13), 1452-1466 (2018)
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