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Merck
CN

SML3665

Palosuran

≥98% (HPLC)

Synonym(s):

1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea, CT-058362

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About This Item

Empirical Formula (Hill Notation):
C25H30N4O2
CAS Number:
540769-28-6
Molecular Weight:
418.53
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
MFCD07772352

Key Documents

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SMILES string

N3(CCC(CC3)(O)Cc4ccccc4)CCNC(=O)Nc1c2c(nc(c1)C)cccc2

InChI

1S/C25H30N4O2/c1-19-17-23(21-9-5-6-10-22(21)27-19)28-24(30)26-13-16-29-14-11-25(31,12-15-29)18-20-7-3-2-4-8-20/h2-10,17,31H,11-16,18H2,1H3,(H2,26,27,28,30)

InChI key

WYJCYXOCHXWTHG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Biochem/physiol Actions

Orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist
Palosuran (ACT-058362) is an orally available, potent, and selective noncompetitive urotensin 2 receptor antagonist. Palosuran decreases serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000235182
0000235181
0000230412
0000230412
0000235182

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Elif Cadirci et al.
Naunyn-Schmiedeberg's archives of pharmacology, 392(2), 135-145 (2018-10-26)
Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in pulmonary, cardiovascular, central nervous, renal and metabolic systems, and especially in inflammatory regions. This study aimed
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 316(3), 1115-1121 (2005-11-04)
Urotensin-II (U-II) is a cyclic peptide that acts through a specific G-protein-coupled receptor, UT receptor. Urotensin-II and UT receptors have been described in pancreas and kidney, but their function is not well understood. We studied the effects of chronic treatment
Martine Clozel et al.
The Journal of pharmacology and experimental therapeutics, 311(1), 204-212 (2004-05-18)
Urotensin-II (U-II) is a cyclic peptide now described as the most potent vasoconstrictor known. U-II binds to a specific G protein-coupled receptor, formerly the orphan receptor GPR14, now renamed urotensin receptor (UT receptor), and present in mammalian species. Palosuran (ACT-058362;

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