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Merck
CN

SML3676

Midecamycin

≥90% (HPLC)

Synonym(s):

Antibiotic SF 837, SF-837

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About This Item

Empirical Formula (Hill Notation):
C41H67NO15
CAS Number:
35457-80-8
Molecular Weight:
813.97
UNSPSC Code:
51284704
NACRES:
NA.21

Key Documents

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InChI

1S/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13+

InChI key

DMUAPQTXSSNEDD-NOGTZZMTSA-N

SMILES string

O=CC[C@H]1C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(C[C@@H](OC(CC)=O)[C@@H]([C@H]1O[C@@H]2[C@@H](O)[C@H](N(C)C)[C@@H](O[C@@H]3C[C@]([C@@H](OC(CC)=O)[C@@H](C)O3)(C)O)[C@H](C)O2)OC)=O

assay

≥90% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Midecamycin is an orally available, broad spectrum macrolide antibiotic produced by Streptomyces mycarofaciens that targets bacterial the 50S ribosomal subunit.
Orally available, broad spectrum macrolide antibiotic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000260211
0000251481
0000260211
0000251481

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T Yoshida et al.
The Japanese journal of antibiotics, 35(6), 1462-1474 (1982-06-01)
In vitro midecamycin acetate was shown to have broad spectrum of antibacterial activities similar to those of other macrolides (midecamycin, josamycin, 9-propionyl josamycin and 2'-ethylsuccinyl erythromycin), which include Gram-positive organisms, a part of Gram-negative organisms and anaerobes. Metabolites of midecamycin
Reut Fallek et al.
The Journal of organic chemistry, 87(15), 9688-9698 (2022-07-09)
Seeking to improve the site selectivity of acylation of amphiphilic diols, which is induced by imidazole-based nucleophilic catalysts and directs the reaction toward apolar sites, as we recently reported, we examined a new improved catalytic design and an alteration of
[Splenic contraction in patients with various disorders].
A Iio et al.
Kaku igaku. The Japanese journal of nuclear medicine, 23(3), 259-266 (1986-03-01)

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