SML3691
Anagrelide analog A6
≥98% (HPLC)
Synonym(s):
6-Chloro-1,5-dihydro-7-(4-methylphenyl)imidazo[2,1-b]quinazolin-2(3H)-one
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About This Item
Empirical Formula (Hill Notation):
C17H14ClN3O
CAS Number:
Molecular Weight:
311.77
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Anagrelide analog A6 is a cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12) forming heterotetrametric complex. Apparently, anagrelide analog A6 binds to the PDE3A enzymatic pocket that allows recruitment and stabilization of SLFN12, which in turn blocks protein translation, leads to apoptosis. It exhibits potent anticancer activity in cell cultures and in a tumor xenograft model.
Cell penetrant and potent apoptosis inducer that works as a molecular glue bringing together phosphodiesterase 3A (PDE3A) and Schlafen 12 protein (SLFN12)
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - STOT RE 2
Target Organs
Cardiovascular
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Jie Chen et al.
Nature communications, 12(1), 6204-6204 (2021-10-29)
Molecular glues are a class of small molecular drugs that mediate protein-protein interactions, that induce either the degradation or stabilization of target protein. A structurally diverse group of chemicals, including 17-β-estradiol (E2), anagrelide, nauclefine, and DNMDP, induces apoptosis by forming
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