SML3712
NG-497
≥98% (HPLC)
Synonym(s):
6-(4-Ethoxyphenyl)-4-methoxy-2-pyridinecarboxylic acid, 1-methylethyl ester, Isopropyl 6-(4-ethoxyphenyl)-4-methoxypicolinate, NG 497, NG497
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About This Item
Empirical Formula (Hill Notation):
C18H21NO4
CAS Number:
Molecular Weight:
315.36
UNSPSC Code:
51111800
NACRES:
NA.25
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C
InChI
1S/C18H21NO4/c1-5-22-14-8-6-13(7-9-14)16-10-15(21-4)11-17(19-16)18(20)23-12(2)3/h6-12H,5H2,1-4H3
InChI key
VYEIBLWRGBQRPI-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
NG-497 is a non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor (IC50 = 1 μM, Ki = 0.5 μM) with little activity toward related human lipid hydrolases or ATGL orthologues from other species (<20% inhibition of mouse, rat, goat, pig, dog, marmoset ATGL at 50 μM). NG-497 abolishes hormone-induced lipolysis in human adipocytes (IC50 = 1.5 and 0.5 μM against 1 μM isoproterenol-induced total or hormonesensitive lipase (HSL)-independent FA release in Simpson-Golabi-Behmel syndrome adipocytes), but not in HepG2 that lacks ATGL hydrolase activity.
Non-cytotoxic, substrate-competitive, reversible and highly selective human/primate adipose triglyceride lipase (ATGL; IPLA2-zeta; PNPLA2) inhibitor.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Gernot F Grabner et al.
Journal of the American Chemical Society, 144(14), 6237-6250 (2022-04-02)
Chronically elevated circulating fatty acid levels promote lipid accumulation in nonadipose tissues and cause lipotoxicity. Adipose triglyceride lipase (ATGL) critically determines the release of fatty acids from white adipose tissue, and accumulating evidence suggests that inactivation of ATGL has beneficial
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