SML3741
GK16S
≥98% (HPLC)
Synonym(s):
(S)-1-Cyano-N-(pent-4-yn-1-yl)pyrrolidine-3-carboxamide (GK16S)
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About This Item
Empirical Formula (Hill Notation):
C11H15N3O
Molecular Weight:
205.26
NACRES:
NA.77
UNSPSC Code:
12352200
Related Categories
Biochem/physiol Actions
GK16S is a non-toxic, chemogenomic control for GK13S to investigate the specific inhibition of UCHL1. GK16S does not exhibit any appreciable degree of inhibition of UCHL1, but engages all lesser targets of GK13S (such as PARK7, C21orf33, ISOC1 andNIT2). GK13S together with GK16S comprises a set of chemogenomic probes for UCHL1, which is suitable for investigation of cellular functions of UCHL.
Non-toxic, chemogenomic control for GK13S to investigate the specific inhibition of UCHL1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Christian Grethe et al.
Nature communications, 13(1), 5950-5950 (2022-10-11)
Ubiquitination regulates protein homeostasis and is tightly controlled by deubiquitinases (DUBs). Loss of the DUB UCHL1 leads to neurodegeneration, and its dysregulation promotes cancer metastasis and invasiveness. Small molecule probes for UCHL1 and DUBs in general could help investigate their
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