SML3746
TFCH
≥98% (HPLC)
Synonym(s):
7-Hydrazinyl-4-(trifluoromethyl)-2H-1-benzopyran-2-one
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About This Item
Empirical Formula (Hill Notation):
C10H7F3N2O2
CAS Number:
Molecular Weight:
244.17
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, Faint yellow to yellow brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Brain penetrant, photo-stable, hydrazinyl coumarin compound that acts as a two-photon highly selective fluorescent sensor for both malondialdehyde and formaldehyde
TFCH is a photo-stable, hydrazinyl coumarin compound that acts as a two-photon fluorescent sensor for biomolecule carbonyls with low biotoxicity and extraordinary biocompatibility. TFCH is blood-brain barrier permeant, highly selective for both malondialdehyde (MDA) and formaldehyde (FA) with low detection levels (0.13 & 0.11 uM), respectively. It is shown to simultaneously and separately detect and image MDA and FA (0.11 uM) levels in living brains (0.37 mg/kg, i.p.) and in PC12 cells by two-photon microscopy. TFCH efficiently detects modest forms of renal injury with much greater sensitivity than standard assays for nephrotoxins. For MDA: Ex 365 & 800 nm, Em 440 nm; For FA: Ex 365 & 800 nm, Em 510 nm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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