SML3769
CWI1-2 Hydrochloride
≥98% (HPLC)
Synonym(s):
N,N′,N′′-Tris(5-chloro-2-hydroxybenzylideneamino)guanidine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C22H17Cl3N6O3·HCl
CAS Number:
Molecular Weight:
556.23
UNSPSC Code:
12352200
NACRES:
NA.21
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=C(O)C(/C=N/N=C(N/N=C/C2=C(O)C=CC(Cl)=C2)N/N=C/C3=C(O)C=CC(Cl)=C3)=C1.Cl
InChI key
UXAOLDYLYMMMRC-SXOKSYETSA-N
Related Categories
Biochem/physiol Actions
CWI1-2 is a cell penetrant, potent and selective inhibitor of an m6A reader IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2). CWI1-2 potently inhibits IGF2BP2 interaction with N6-Methyladenosine (m6A) modified target transcripts. CWI1-2 exhibits potent anti-leukemia efficacy in vitro and in vivo.
Cell penetrant, potent and selective inhibitor of an m6A reader IGF2BP2
Disclaimer
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Synthesis of Novel N,N?,N?-Tris[aryl(hetaryl)-methylideneamino]guanidine Derivatives as Efficient and Selective Colorimetric Sensors for Fluoride Ion
Russian Journal of Organic chemistry (2019)
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia
Cancer Cell, 40(12), 1566-1582 (2022)
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