Skip to Content
Merck
CN

SML3776

Sigma-Aldrich

AZD1080

≥98% (HPLC)

Synonym(s):

2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, AZ1080, AZD 1080

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C19H18N4O2
CAS Number:
612487-72-6
Molecular Weight:
334.37
MDL number:
MFCD12913314
UNSPSC Code:
12352200
NACRES:
NA.21

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, Faint yellow to yellow brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

N4(CCOCC4)Cc1cnc(cc1)c2c3c([nH]c2O)ccc(c3)C#N

InChI

1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2

InChI key

BLTVBQXJFVRPFK-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

AZ1080 is a brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression. AZ1080 enhances CD8+ T-cell function in cancer, and is as effective as ant-PD-1 in controlling of B16 melanoma and EL4 lymphoma growth in mice.
Brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000252740
0000252741
0000244443
0000252740
0000252741

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Laura Caberlotto et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(10), 893-903 (2013-06-25)
Glycogen synthase kinase (GSK3) is a constitutively active serine-threonine kinase associated to neurological and psychiatric disorders. GSK3 inhibition is considered a mediator of the efficacy of the mood-stabiliser lithium. This study aimed at comparing the central nervous system effect of
Alison Taylor et al.
Cancer research, 78(3), 706-717 (2017-10-22)
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase, GSK-3α/β, is a central regulator of PD-1 transcription in CD8+ T cells.
Shanshan Hu et al.
Neuropsychiatric disease and treatment, 16, 651-663 (2020-03-19)
Parkinson's disease (PD) is the second most common neurodegenerative disease. The α-Synuclein is a major component of Lewy bodies and Lewy neurites, the pathologic hallmark of PD. It is known that α-Synuclein is phosphorylated (p-α-Synuclein) in PD and tau-hyperphosphorylation (p-Tau)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service