SML3787
Pexiganan acetate
≥98% (HPLC)
Synonym(s):
GIGKFLKKAKKFGKAFVKILKK-NH2 acetate, Gly-Ile-Gly-Lys-Phe-Leu-Lys-Lys-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Lys-Ile-lIe-Lys-Lys-NH2 acetate, MSI 78 acetate, MSI-78 acetate, MSI78 acetate
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About This Item
Empirical Formula (Hill Notation):
C122H210N32O22 · xC2H2O4
CAS Number:
Molecular Weight:
2477.17 (free base basis)
NACRES:
NA.21
UNSPSC Code:
12352200
Product Name
Pexiganan acetate, ≥98% (HPLC)
assay
≥98% (HPLC)
form
(Powder or Lyophilized powder or film)
storage condition
desiccated
color
white to off-white
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Cationic antimicrobial peptide (AMP) with broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Pexiganan (MSI-78) is a 22-aa synthetic cationic antimicrobial peptide (AMP), an analog of magainin found in the African clawed frog (Xenopus laevis). Pexiganan is effective against both Gram-positive (staphylococci MIC ≤16 µg/mL, streptococci & methicillin-resistant S. aureus MIC 8-64 µg/mL, S. pyrogenes MIC 16-256 µg/mL) and Gram-negative aerobes (MIC 4-32 µg/mL, E. cloacae MCI 1-128 µg/mL, A. faecalis 4-64 µg/mL) by disrupting bacteria cell wall or membrane.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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H M Lamb et al.
Drugs, 56(6), 1047-1052 (1999-01-08)
Pexiganan acetate (MSI 78) is a synthetic cationic peptide (22 amino acids) with antibacterial activity. It is an analogue of magainin 2, which is a host defence peptide isolated from frog skin. The drug is thought to act by disturbing
P C Fuchs et al.
Antimicrobial agents and chemotherapy, 42(5), 1213-1216 (1998-05-21)
MSI-78 is a cationic peptide with broad-spectrum antimicrobial activity and is being developed as a topical agent. We compared the in vitro activity of MSI-78 with those of ofloxacin and other antibiotics against fresh clinical isolates. Based on MIC distribution
Alexandro Rodríguez-Rojas et al.
Frontiers in immunology, 11, 1686-1686 (2020-11-03)
Cationic antimicrobial peptides (AMPs) are active immune effectors of multicellular organisms and are also considered as new antimicrobial drug candidates. One of the problems encountered when developing AMPs as drugs is the difficulty of reaching sufficient killing concentrations under physiological
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